ABSTRACT
Objective: To observe value of 3D navigation assisted percutaneous vertebroplasty (PVP) combined with postoperative lower-back muscles training in treatment of osteoporotic vertebral compression fracture (OVCF). Methods: Twenty-five consecutive patients with OVCF were enrolled in observation group and treated with 3D navigation assisted PVP using O-arm scanner and postoperatively systematic back muscle exercise, while other 25 OVCF patients in control group were treated with traditional C-arm assisted PVP and postoperatively regular back muscle exercise. Intraoperative fluoroscopy time, mean dose of radiation, mean procedure time, visual analogue score (VAS) before and 2 h, 1 month, 3 months, 6 months after operation were compared between the two groups. Technical success rate was calculated, and vertebral leakages and complications were observed. Results: Technical success rate of the two groups were both 100% (25/25). The duration of fluoroscopy and operation were shorter, the radiation dose was lower in observation group (all P0.05). Conclusion: PVP guided with 3D navigation combined with postoperative lumbar and dorsal muscle training can safely and effectively treat OVCF, shorten the operation time, reduce radiation exposure and improve the medium and long-term pain symptoms after PVP.
ABSTRACT
BACKGROUND: Current treatmemt strategy cannot efficiently relieve or reverse the disk degeneration, and neither surgical treatment nor nonsurgical treatment has gained satisfactory long-term effect. Therefore, more and more researches have focused on the cell therapy. OBJECTIVE: To explore the present states and application prospect of cell therapy, especially stem cells for degenerative intervertebral disc repair.METHODS: A computer-based search for related articles in PubMed database published between January 2011 and January 2016 using the English keywords of stem cell, intervertebral disk degeneration. Literatures addressing cell therapy for degenerative intervertebral disc repair were selected, and the articles published lately or original researches in authoritative journals were preferred.RESULTS AND CONCLUSION: A total of 205 articles were selected firstly, and 50 eligible articles were enrolled finally in accordance with the inclusion criteria. The mixtures of stem cells and carrier are injected into the degenerative intervertebral disk, to repair or displace abnormal cells. This strategy has been accepted by many researchers, and considered as a promising treatment. However, there is little evidence about the safety of clinical treatment with cell therapy, which still needs to be explored in depth.